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Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface
Published on: May 21, 2015
Perinatal deaths and lymphatic system involvement: a diagnostic flow-chart applying immunohistochemical methods
C Bellini1, M Rutigliani, F Boccardo
1Neonatal Intensive Care Unit, Department of Pediatrics, University of Genoa, I.R.C.C.S. Gaslini Institute, Genoa, Italy. carlobellini@ospedale-gaslini.ge.it
Lymphology
|December 15, 2011
Summary
A diagnostic flowchart aids in perinatal death cases with hydrops fetalis or increased nuchal translucency. Recommended immunohistochemical staining aids in diagnosis.
Area of Science:
- Perinatal pathology
- Fetal diagnostics
- Immunohistochemistry
Background:
- Non-immune hydrops fetalis, visceral effusions, and increased nuchal translucency are critical indicators in perinatal death.
- Accurate diagnosis is essential for understanding causes and recurrence risks.
Purpose of the Study:
- To present a diagnostic flowchart for perinatal death with specific fetal anomalies.
- To recommend specific immunohistochemical markers for diagnostic confirmation.
Main Methods:
- Development of a diagnostic algorithm for stillbirth cases.
- Application of immunohistochemical staining using CD-31, CD-34, D2-40, and smooth muscle actin.
Main Results:
- The flowchart provides a structured approach to diagnosing complex perinatal deaths.
- Immunohistochemistry aids in identifying specific cellular and vascular features.
Conclusions:
- The proposed diagnostic flowchart and recommended immunohistochemical panel can improve the diagnostic yield in challenging perinatal death cases.
- This approach assists in identifying underlying pathologies contributing to fetal demise.
