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Related Experiment Video

Updated: May 26, 2026

Vascular Gene Transfer from Metallic Stent Surfaces Using Adenoviral Vectors Tethered through Hydrolysable Cross-linkers

Vascular Gene Transfer from Metallic Stent Surfaces Using Adenoviral Vectors Tethered through Hydrolysable Cross-linkers

Published on: August 12, 2014

[Carotid stenting versus endarterectomy].

Naoki Toma¹, Waro Taki

¹Department of Neurosurgery, Mie University Graduate School of Medicine, Tsu, Japan.

Nihon Geka Gakkai Zasshi

|December 15, 2011

Summary

Carotid artery stenting (CAS) is a viable alternative to carotid endarterectomy (CEA) for stroke prevention. Recent trials show comparable outcomes, though interpretation remains debated.

Area of Science:

Vascular Surgery
Interventional Cardiology
Neurology
Stroke Prevention

Background:

Carotid atherosclerotic disease poses a significant stroke risk.
Carotid endarterectomy (CEA) is a traditional surgical intervention.
Carotid artery stenting (CAS) offers a less invasive endovascular alternative.

Purpose of the Study:

To compare the efficacy and safety of CAS versus CEA for stroke prevention.
To analyze results from recent multicenter, randomized trials.
To address the ongoing controversy in interpreting trial outcomes.

Main Methods:

Review of five multicenter, randomized trials comparing CAS and CEA.
Analysis of outcomes in high-risk, symptomatic average-risk, and conventional-risk patients.

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Last Updated: May 26, 2026

Vascular Gene Transfer from Metallic Stent Surfaces Using Adenoviral Vectors Tethered through Hydrolysable Cross-linkers

Vascular Gene Transfer from Metallic Stent Surfaces Using Adenoviral Vectors Tethered through Hydrolysable Cross-linkers

Published on: August 12, 2014

Inclusion of data from a postapproval study of CAS in Japan.

Main Results:

One trial in high-risk patients showed CAS non-inferiority to CEA.
Trials in symptomatic average-risk patients suggested CEA superiority.
A large-scale trial in conventional-risk patients found similar results for CAS and CEA.
A Japanese postapproval study indicated acceptable CAS outcomes.

Conclusions:

CAS is a comparable alternative to CEA for stroke prevention in specific patient groups.
Trial interpretations vary, highlighting the need for careful patient selection.
Further research may clarify optimal treatment strategies for carotid atherosclerotic disease.