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Related Experiment Videos

Foetal hepatic calcification.

N D Hawass1, M G el Badawi, J A Fatani

  • 1Department of Radiology, King Saud University Hospital, Kingdom of Saudi Arabia.

Pediatric Radiology
|January 1, 1990
PubMed
Summary

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Hepatic calcifications in spontaneously aborted fetuses, including calcified hepatic vein thrombi (CHVT) and calcified portal vein thrombi (CPVT), are linked to severe fetal illnesses and maternal factors. Awareness aids prenatal ultrasound detection.

Area of Science:

  • Perinatology
  • Fetal Pathology
  • Radiology

Background:

  • Hepatic calcifications are observed in spontaneously aborted fetuses.
  • These calcifications can occur in hepatic veins, portal veins, or parenchyma.

Purpose of the Study:

  • To investigate the types and incidence of hepatic calcifications in aborted fetuses.
  • To correlate these findings with associated fetal anomalies and maternal factors.
  • To assess the potential for prenatal ultrasound detection.

Main Methods:

  • Analysis of 1,500 spontaneously aborted fetuses.
  • Identification and classification of hepatic calcifications (CHVT, CPVT, parenchymal).
  • Confirmation via contrast studies, dissection, and histology.
  • Correlation with fetal anomalies and maternal history.
Keywords:
Abortion, SpontaneousAge FactorsAnthropometryBiologyDemographic FactorsDiseasesEconomic FactorsExaminations And DiagnosesFertilityFertility MeasurementsHepatic EffectsHistologyIncidenceLaboratory Examinations And DiagnosesMeasurementParityPhysiologyPopulationPopulation CharacteristicsPopulation DynamicsPregnancy ComplicationsResearch MethodologySocioeconomic FactorsUltrasonics

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Main Results:

  • Thirty-three fetuses (2.2%) exhibited hepatic calcifications.
  • Common types included calcified hepatic vein thrombi (CHVT) and calcified portal vein thrombi (CPVT).
  • High incidence of associated anomalies (85%), notably meconium intraluminal calcification, cystic hygroma, and metaphyseal defects.
  • Maternal factors showed peak incidence in the third decade, with 33% on contraceptive pills and an inverse relationship with gravidity.

Conclusions:

  • Severe fetal illnesses likely predispose to CHVT and CPVT.
  • Maternal contraceptive pill use and lower gravidity are associated with hepatic calcifications.
  • Increased awareness can improve prenatal diagnosis of hepatic calcifications via ultrasound.