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Hepatic dysfunction in children with tuberculosis on treatment with antituberculous therapy
1Incharge, Pediatric Tuberculosis Clinic, B.J. Wadia Hospital for Children, Parel, Mumbai, India.
Annals of Hepatology
|December 15, 2011
Summary
Drug-induced liver injury occurred in 15.2% of pediatric tuberculosis patients. Younger children under 3.5 years on anti-tuberculous treatment (ATT) showed increased risk, necessitating regular SGPT monitoring.
Area of Science:
- Pediatric Hepatology
- Infectious Diseases
- Pharmacovigilance
Background:
- Drug-induced liver injury (DILI) is a significant concern in children undergoing anti-tuberculous treatment (ATT).
- Identifying risk factors for DILI is crucial for optimizing treatment protocols and patient safety.
Purpose of the Study:
- To determine the incidence of drug-induced hepatic dysfunction in children receiving ATT.
- To identify factors associated with hepatic dysfunction in this pediatric population.
Main Methods:
- A prospective study was conducted involving 46 children with tuberculosis on ATT.
- Serum glutamic pyruvic transaminase (SGPT) levels were monitored regularly and upon symptom development.
- Statistical analysis (SPSS v15.0) was used to assess associations between DILI and factors like age, sex, weight, malnutrition, and tuberculosis severity.
Main Results:
- Seven out of 46 children (15.2%) developed drug-induced hepatic dysfunction during ATT.
- Liver dysfunction was significantly associated with younger age (under 3.5 years; p=0.025).
- No significant association was found with sex, weight, malnutrition, or tuberculosis type/severity.
Conclusions:
- Regular monitoring of SGPT levels is recommended for all children on ATT, particularly those under 3.5 years.
- Early detection and intervention can mitigate the risks associated with ATT-related liver injury in children.
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