Glisson's capsule blistering after hyperthermic intraperitoneal chemotherapy.
Heriberto Medina-Franco1, Daniel Zamora-Valdés, Ariadne Sánchez-Ramón
1Department of Surgery, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán (INCMNSZ), México, D.F. herimd@hotmail.com
Annals of Hepatology
|December 15, 2011
Summary
Hyperthermic intraperitoneal chemotherapy can cause blistering of the Glisson's capsule, a previously unreported side effect. Fortunately, this complication did not lead to any patient morbidity.
Area of Science:
- Oncology
- Surgical Oncology
- Gastroenterology
Background:
- Hyperthermic intraperitoneal chemotherapy (HIPEC) is a standard treatment for peritoneal carcinomatosis.
- Cytoreductive surgery followed by HIPEC improves survival in select malignancies.
- Peritoneal spread necessitates multimodal treatment strategies.
Observation:
- A novel observation during HIPEC procedures was noted.
- Blistering of the Glisson's capsule, a part of the liver's connective tissue, was identified.
- This finding was documented in patients undergoing HIPEC post-cytoreduction.
Findings:
- Glisson's capsule blistering is a previously unreported consequence of HIPEC.
- The observed blistering did not correlate with increased patient morbidity.
- This suggests a localized and non-consequential effect of HIPEC on the liver capsule.
Implications:
- Clinicians should be aware of potential Glisson's capsule blistering during HIPEC.
- Further research may elucidate the exact mechanism of HIPEC-induced blistering.
- The findings support the continued use of HIPEC without modification due to this specific observation.
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