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Updated: May 26, 2026
Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures
Published on: January 9, 2019
Analysis of isocitrate dehydrogenase-1/2 gene mutations in gliomas
Lei Yu1, Song-Tao Qi, Zhi-Yong Li
1Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangdong, Guangzhou 510515, China.
Objective:
To highlight recent researches which may show promise for histomolecular classification and new treatments for gliomas.
Data Sources:
All articles cited in this review were mainly searched from PubMed, which were published in English from 1996 to 2010.
Study Selection:
Original articles and critical reviews selected were relevant to the isocitrate dehydrogenase-1/2 mutation in gliomas and other tumors.
Results:
Extraordinary high rates of somatic mutations in isocitrate dehydrogenase-1/2 occur in the majority of World Health Organization grade II and grade III gliomas as well as grade IV secondary glioblastomas. Isocitrate dehydrogenase-1/2 mutations are associated with younger age at diagnosis and a better prognosis in patients with mutated tumors. The functional role of isocitrate dehydrogenase-1/2 mutations in the pathogenesis of gliomas is still unclear.
Conclusion:
Isocitrate dehydrogenase-1/2 mutations define a specific subtype of gliomas and may have great significance in the diagnosis, prognosis, and treatment of patients with these tumors.
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