[Treatment of hypertension using angiotensin-converting enzyme inhibitors]

Angiotensin conversion enzyme inhibitors (ACE inhibitors) comprise a relatively new group of potent antihypertensives. They are today among the most used preparations for reducing blood pressure. ACE inhibitors may be used for treatment of almost all forms and degrees of hypertension. By reason of the reduction of the resistance in the peripheral vessels the blood pressure drops by 12-20 per cent, both at rest and during muscular effort, without diminution of the heart's pump function. The autonomic reflexes are unchanged and the circulation in the kidneys and the brain is retained. ACE inhibition does not result in fluid retention. In adequate doses the drugs are tolerated and give few side-effects provided that the patient is not dehydrated.