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Crystal and solution structures of the oligonucleotide d(ATGCGCAT)2: a combined X-ray and NMR study
G R Clark1, D G Brown, M R Sanderson
1Cancer Research Campaign Biomolecular Structure Unit, Institute of Cancer Research, Sutton, Surrey, UK.
Nucleic Acids Research
|September 25, 1990
Abstract:
A combined crystal-structure determination and NMR analysis of the octanucleotide d(ATGCGCAT)2 is reported. The X-ray analysis shows that the structure is A-form duplex in crystal state. The NMR study shows that in solution this sequence is B-type. The conformational results from each technique are presented in detail. The implications of these findings in terms of conformational flexibility and ligand binding are discussed.