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Quantifying local stiffness variations in radiofrequency ablations with dynamic indentation.

Ryan J DeWall1, Tomy Varghese, Christopher L Brace

  • 1Department of Medical Physics, University of Wisconsin-Madison, Madison, WI 53705, USA. dewall@wisc.edu

IEEE Transactions on Bio-Medical Engineering
|December 15, 2011
PubMed
Summary

Elastography can monitor radiofrequency ablation, but low stiffness contrast at the periphery may underestimate the ablation boundary. This study quantifies stiffness variations to improve boundary determination for complete pathological target treatment.

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Area of Science:

  • Biomedical Engineering
  • Medical Imaging
  • Materials Science

Background:

  • Elastography is crucial for monitoring ablation procedures.
  • Accurate ablation boundary determination ensures complete treatment of pathological targets.

Purpose of the Study:

  • To investigate the potential of elastographic images for representing ablation boundaries.
  • To quantify local viscoelastic property variations in radiofrequency-ablated liver tissue.

Main Methods:

  • Dynamic indentation was used to quantify viscoelastic properties in porcine liver tissue post-radiofrequency ablation.
  • Spatial stiffness maps were correlated with stained histology.
  • Elastographic imaging modalities were compared to gross pathology in bovine liver tissue.

Main Results:

  • Storage modulus and stiffening rate were highest in the central ablation zone, decreasing radially.
  • Low stiffness contrast at the ablation periphery was observed.
  • Elastography underestimated ablation extent compared to gross pathology.

Conclusions:

  • Spatial stiffness distributions within radiofrequency ablations were elucidated.
  • Low stiffness contrast on the ablation periphery leads to underestimation of ablation extent in elastographic images.
  • Further research is needed to improve elastography's accuracy in defining ablation boundaries.