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Updated: May 26, 2026
08:45
Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes
Published on: May 10, 2022
[Increased iron store and its relationship with cardiovascular disease]
Tomás Meroño1, Patricia Sorroche, Fernando D Brites
1Departamento de Bioquímica Clínica, Universidad de Buenos Aires, Buenos Aires, Argentina. tomasmero@yahoo.com.ar
Medicina
|December 15, 2011
Summary
Increased iron stores may contribute to cardiovascular disease (CVD) risk, challenging the "iron hypothesis." New insights into iron metabolism and hepcidin offer explanations for past inconsistencies regarding iron overload and CVD.
Area of Science:
- Biochemistry
- Cardiovascular Medicine
- Hematology
Context:
- Cardiovascular disease (CVD) incidence remains high despite advances in managing traditional risk factors.
- Increased iron stores are increasingly recognized as a potential contributor to CVD.
- The
- Purpose: [
- Summary: [
- Impact: [
Purpose:
- To review current knowledge on iron overload as a CVD risk factor.
- To explore the role of iron metabolism and hepcidin in CVD pathogenesis.
- To reconcile controversial findings regarding iron levels and cardiovascular health.
Summary:
- Recent advances in understanding iron metabolism, particularly the hormone hepcidin, provide new frameworks for evaluating iron's role in CVD.
- The review examines the association between inflammation, iron regulation, and the potential risk posed by elevated iron stores.
- Contradictory results from studies on the
- Impact: [
Impact:
- Offers a current perspective on iron overload and cardiovascular risk, integrating new findings on iron metabolism and inflammation.
- Provides a basis for re-evaluating the
- iron hypothesis
- and its clinical implications.
- Highlights the potential significance of hepcidin in understanding and potentially managing CVD risk related to iron dysregulation.
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