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Updated: May 26, 2026

Fully Endoscopic Mitral Valve Repair with Percutaneous Cannulation of Groin Vessels
Published on: May 26, 2023
Mitral valve repair is underused in patients with hypertrophic obstructive cardiomyopathy
Christina M Vassileva1, Theresa Boley, Stephen Markwell
1Division of Cardiothoracic Surgery, Southern Illinois University School of Medicine, Springfield, Illinois 62794-9638, USA. cvassileva@siumed.edu
Insights
Mitral valve replacement is more common than repair in hypertrophic obstructive cardiomyopathy (HOCM) patients. Repair offers better outcomes with lower mortality and shorter hospital stays, suggesting specialized centers improve HOCM surgical results.
Area of Science:
- Cardiovascular Surgery
- Cardiac Surgery Outcomes
- Medical Database Analysis
Background:
- Optimal surgical strategy for hypertrophic obstructive cardiomyopathy (HOCM) with mitral valve (MV) regurgitation remains debated.
- Previous studies lack comprehensive data on current treatment patterns for HOCM patients with MV pathology.
Purpose of the Study:
- To analyze the most frequent surgical approach for mitral valve (MV) pathology in patients diagnosed with hypertrophic obstructive cardiomyopathy (HOCM).
- To compare outcomes of mitral valve (MV) repair versus replacement in HOCM patients using a large national database.
Main Methods:
- Utilized the Nationwide Inpatient Sample (NIS) database (2005-2008).
- Identified HOCM patients undergoing either MV repair or replacement.
- Compared baseline characteristics, repair rates, hospital mortality, and length of stay (LOS).
Main Results:
- Mitral valve (MV) repair was performed in 17.2% of hypertrophic obstructive cardiomyopathy (HOCM) cases.
- Hospital mortality was significantly lower for MV repair (0.00%) compared to replacement (11.18%).
- Median length of stay (LOS) was shorter for MV repair (7 days) versus replacement (11 days).
Conclusions:
- The majority of hypertrophic obstructive cardiomyopathy (HOCM) patients undergo mitral valve (MV) replacement.
- Mitral valve (MV) repair is associated with superior operative outcomes in HOCM patients.
- Referral to specialized centers may improve surgical outcomes for HOCM patients with MV pathology.
Background:
The optimal surgical approach for patients with hypertrophic obstructive cardiomyopathy (HOCM) with concomitant mitral valve (MV) regurgitation has remained controversial. The purpose of this study was to use the largest all-payer database in the United States to examine the strategy most commonly used for the correction of mitral valve pathology in the setting of HOCM.
Methods:
The Nationwide Inpatient Sample (NIS) database was searched from 2005 to 2008 to identify patients with a diagnosis of HOCM (ICD-9-CM code 425.1) who underwent MV repair (ICD-9-CM code 35.12) or replacement (ICD-9-CM codes 35.23 and 35.24). HOCM patients who underwent MV repair and those who underwent MV replacement were compared with respect to baseline characteristics, repair rates, hospital mortality, and length of stay (LOS).
Results:
MV repair was performed in 17.2% of cases (219/1255). Repair rates did not show a significantly increasing trend over time (P = .1419). The median LOS was significantly longer for replacement than for repair (11 days versus 7 days, P = .0001). The mortality rate for patients who underwent repair was 0.00%, compared with 11.18% for those who underwent replacement (P < .05).
Conclusions:
The majority of patients with a HOCM diagnosis underwent MV replacement for the correction of MV pathology. Referral to centers with special expertise in treating patients with HOCM may positively affect the operative outcomes of this patient subset.
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