[Pathogenetic mechanisms and morphological manifestations of medical liver damage]

In the review of literature the modern data on mechanisms of development, features of pathogenesis and morphological appearance of drug-induced lesions of liver are presented. The cytotoxic lesions resulting in development of acute or chronic hepatitis, cholestatic lesions linked to structural changes in elements of bile excretion system or mechanisms of formation of bile are illustrated. The morphological features of infringement of a lipid metabolism in hepatocytes with development of steatosis of liver and steatohepatitis are described also. In some cases the influence of medicaments resulted in the damage of vascular network of liver, in accumulation of pigments, development of granulomas and liver fibrosis is observed. The main morphological signs of drug-induced lesions of liver are illustrated on the own histological data from liver biopsies.