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Updated: May 26, 2026

Detection and Monitoring of Tumor Associated Circulating DNA in Patient Biofluids
Published on: June 8, 2019
Detection of single nucleotide polymorphisms within a sequence of a gene associated with prostate cancer using a
Zheng-Yun Zhao1, Marie San, Jean-Louis H A Duprey
1School of Chemistry, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
Abstract:
Single nucleotide polymorphisms within a sequence of a gene associated with prostate cancer were identified using oligodeoxynucleotide probe sequences bearing internal anthracene fluorophores proximal to the SNP site. Depending upon the nature of the synthesised target sequences, probe-target duplex formation could lead to enhanced or attenuated fluorescence emission from the anthracene, enabling detection of a proximal base-pair as either matching or mismatching.
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