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Related Concept Videos

Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
Role of Hematopoietic Growth Factors01:28

Role of Hematopoietic Growth Factors

Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
Thrombopoietin (TPO), mainly released by the liver,...
Overview of Hematopoiesis01:20

Overview of Hematopoiesis

Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
Hematopoiesis01:21

Hematopoiesis

The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...

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Related Experiment Video

Updated: May 26, 2026

Stimulation of Notch Signaling in Mouse Osteoclast Precursors
08:01

Stimulation of Notch Signaling in Mouse Osteoclast Precursors

Published on: February 28, 2017

[Progress of study on Notch and hematologic malignancies].

Yi-Ran Zhao1, Rong Fu

  • 1Department of Hematology, Tianjin Medical University General Hospital, Tianjin, China.

Zhongguo Shi Yan Xue Ye Xue Za Zhi
|December 16, 2011
PubMed
Summary

The Notch signaling pathway plays a dual role in cancer, acting as both oncogenic and tumor suppressive. This review explores Notch1 mutations in T-cell acute lymphoblastic leukemia (T-ALL) and its clinical implications.

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Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome

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Last Updated: May 26, 2026

Stimulation of Notch Signaling in Mouse Osteoclast Precursors
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Published on: February 28, 2017

Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome
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Area of Science:

  • Molecular Biology
  • Cell Signaling
  • Oncology

Context:

  • Notch signaling is crucial for cell development and implicated in malignancies.
  • Notch1 mutations are frequent in T-cell acute lymphoblastic leukemia (T-ALL).
  • The precise role of Notch signaling in cancer pathogenesis is complex and context-dependent.

Purpose:

  • To review recent findings on Notch signaling in hematologic malignancies.
  • To examine Notch1 mutations in T-ALL and their significance.
  • To discuss the interplay between Notch signaling and other pathways in cancer.
  • To explore the clinical potential of Notch inhibitors.

Summary:

  • Notch signaling, involving receptors, ligands, and effectors, regulates cell processes and is implicated in cancer.
  • Activating Notch1 mutations are found in over 50% of T-ALL cases, but their timing as an early or secondary event remains unclear.
  • This review covers Notch signaling in hematologic cancers, Notch1 mutations in T-ALL, pathway interactions, and therapeutic prospects of Notch inhibitors.

Impact:

  • Provides insights into the complex role of Notch signaling in hematologic malignancies.
  • Highlights the significance of Notch1 mutations in T-ALL pathogenesis.
  • Discusses potential therapeutic strategies targeting the Notch pathway for cancer treatment.