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Th17 Inflammation Model of Oropharyngeal Candidiasis in Immunodeficient Mice
Published on: February 18, 2015
Host defence against Candida albicans and the role of pattern-recognition receptors
Gerd G Gauglitz1, Helene Callenberg, Günther Weindl
1Department of Dermatology and Allergology, Ludwig-Maximilian-University, D-80337 Munich, Germany. Gerd.Gauglitz@med.uni-muenchen.de
Abstract:
Recognition of Candida albicans is mediated by several classes of pattern-recognition receptors, including Toll-like receptors and C-type lectin receptors. Cell wall components of C. albicans, interact with the pattern-recognition receptors, which are expressed by different cells, primarily antigen-presenting cells. This review aims to discuss the different pattern-recognition receptors responsible for recognition of special structures of C. albicans, which are known to activate intracellular signals that finally lead to directed and efficient host defence.
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