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Updated: May 26, 2026

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
12:42

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Published on: January 7, 2019

Measles virus causes immunogenic cell death in human melanoma

O G Donnelly1, F Errington-Mais, L Steele

  • 1Leeds Institute for Molecular Medicine, University of Leeds, Leeds, UK.

Gene Therapy
|December 16, 2011
PubMed

Insights

Measles virus (MV) effectively targets human melanoma, demonstrating its potential as an oncolytic virus (OV) therapy. This study shows MV enhances innate immunity and stimulates adaptive immune responses against melanoma.

Area of Science:

  • Oncology
  • Virology
  • Immunology

Background:

  • Oncolytic viruses (OV) are emerging cancer therapeutics in clinical trials.
  • Measles virus (MV) has not been previously evaluated in human melanoma models.

Purpose of the Study:

  • To investigate the efficacy of MV against human melanoma.
  • To explore MV's role in modulating host antitumour immune responses.

Main Methods:

  • Utilized human in vitro models of melanoma.
  • Assessed MV-mediated melanoma cell death and its impact on immune responses.

Main Results:

  • Demonstrated MV's efficacy in targeting human melanoma cells.
  • Showcased MV-induced cell death as an inflammatory process, releasing cytokines and HMGB1.
  • Confirmed MV enhances innate antitumour activity.
  • Established that MV stimulates a melanoma-specific adaptive immune response.

Conclusions:

  • MV is a viable oncolytic virus for human melanoma treatment.
  • MV therapy can potentiate both innate and adaptive antitumour immunity.

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