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Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

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Fluid and white matter suppression with the MP2RAGE sequence.

Mark Tanner¹, Giulio Gambarota, Tobias Kober

¹GlaxoSmithKline, Clinical Imaging Center, Imperial College, London, UK.

Journal of Magnetic Resonance Imaging : JMRI

|December 16, 2011

Summary

A new magnetic resonance imaging (MRI) sequence, FLAWS, creates two image sets from one scan. This offers improved brain structure visualization for clinical diagnosis and segmentation algorithms.

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Area of Science:

Neuroimaging
Medical Physics
Radiology

Background:

Magnetic resonance imaging (MRI) is crucial for brain structure analysis.
Existing sequences like MPRAGE and FGATIR provide specific contrasts but require separate acquisitions.
Optimizing MRI acquisition for detailed brain anatomy is an ongoing research area.

Purpose of the Study:

To develop a novel MRI sequence named FLAWS (fluid and white matter suppression).
FLAWS aims to generate two distinct image contrasts from a single scan.
The sequence is designed for enhanced structural definition and subcortical brain structure delineation.

Main Methods:

The study utilized the MP2RAGE sequence, a modification of MPRAGE.
FLAWS was implemented to produce two image sets: FLAWS1 (FGATIR-like) and FLAWS2 (MPRAGE-like).
Five healthy volunteers were scanned at 3T to evaluate image quality.

Main Results:

FLAWS1 and FLAWS2 demonstrated comparable tissue contrast and contrast-to-noise ratios to FGATIR and MPRAGE, respectively.
Synthetic minimum value images from FLAWS yielded a gray matter-dominant contrast.
The sequence successfully generated two coregistered 3D volumes.

Conclusions:

FLAWS provides two coregistered datasets with distinct contrasts: one with suppressed white matter and another with suppressed cerebrospinal fluid.
The dual-contrast capability enhances the delineation of subcortical brain structures.
FLAWS shows potential utility in neuroimaging segmentation algorithms and clinical diagnostics.