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Multidrug-resistant Streptococcus pneumoniae serotype 6D clones in South Korea

Kwan Soo Ko1, Jin Yang Baek, Jae-Hoon Song

  • 1Department of Molecular Cell Biology, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon, South Korea. ksko@skku.edu

Journal of Clinical Microbiology
|December 16, 2011
PubMed

Insights

Multidrug-resistant Streptococcus pneumoniae serotype 6D clones in South Korea exhibit distinct genetic backgrounds. Clone ST282(6D) likely emerged through recombination and capsular switching, unlike ST3171(6D).

Area of Science:

  • Microbiology
  • Genetics
  • Epidemiology

Background:

  • Streptococcus pneumoniae serotype 6D is an emerging clone.
  • Understanding its genetic characteristics and antimicrobial resistance is crucial.

Purpose of the Study:

  • To investigate the genetic features and antimicrobial susceptibility of Streptococcus pneumoniae serotype 6D clones (ST282 and ST3171) in South Korea.
  • To compare these clones with a related serotype 6A clone (ST81).

Main Methods:

  • Antimicrobial susceptibility testing was performed on isolates.
  • Sequencing of 11 genes around the cps locus was conducted for ST282(6D), ST3171(6D), and ST81(6A) isolates.

Main Results:

  • ST81(6A) and ST282(6D) showed similar antimicrobial resistance patterns (penicillin, cefuroxime, ceftriaxone, trimethoprim-sulfamethoxazole).
  • ST3171(6D) isolates were resistant only to macrolides and clindamycin.
  • Genetic analysis revealed shared backgrounds between ST81(6A) and ST282(6D), but distinct backgrounds for ST3171(6D).
  • Mosaic structure in the dexB gene of ST282(6D) suggests recombination.

Conclusions:

  • The multidrug-resistant ST282(6D) clone likely emerged via genetic recombination, including capsular switching.
  • ST3171(6D) represents a genetically distinct serotype 6D clone.

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