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Related Concept Videos

Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
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Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
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Urinary Tract Infection II: Pathophysiology

The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
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Related Experiment Video

Updated: May 26, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Published on: February 9, 2011

Metastatic complications from Staphylococcus intermedius, a zoonotic pathogen.

Steven Hatch1, Aruna Sree, Sandra Tirrell

  • 1University of Massachusetts Medical School, Worcester, Massachusetts, USA. steven.hatch@umassmed.edu

Journal of Clinical Microbiology
|December 16, 2011
PubMed
Summary

Metastatic infection is rare in non-Staphylococcus aureus staphylococcal cases. This report details a unique case of bloodstream infection caused by Staphylococcus intermedius, highlighting its metastatic potential.

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Area of Science:

  • Infectious Diseases
  • Microbiology
  • Clinical Medicine

Background:

  • Metastatic infection is an uncommon complication of staphylococcal bacteremia.
  • Non-aureus staphylococci are typically associated with localized infections.
  • Staphylococcus intermedius is a known pathogen, but metastatic potential is poorly documented.

Observation:

  • A case of bloodstream infection (bacteremia) caused by Staphylococcus intermedius is presented.
  • The patient developed a metastatic infection, a rare occurrence for this species.
  • This represents the first reported instance of metastatic infection attributed to S. intermedius.

Findings:

  • Staphylococcus intermedius can cause severe systemic infections.
  • Metastatic complications, such as abscess formation or seeding of distant organs, can occur.
  • The clinical presentation and management of S. intermedius bacteremia with metastatic spread may differ from S. aureus.

Implications:

  • Highlights the need to consider S. intermedius as a potential cause of metastatic infections.
  • May prompt further research into the virulence factors and pathogenic mechanisms of S. intermedius.
  • Clinicians should be aware of the possibility of metastatic disease in patients with S. intermedius bacteremia.