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Updated: May 26, 2026

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
Sodium oxybate and sleep apnea: a clinical case
Sarah Hartley1, Maria-Antonia Quera-Salva, Mourad Machou
1AP-HP Hôpital Raymond Poincaré, Sleep Unit, Physiology Department, Versailles-St Quentin en Yvelines University, France. sarah.hartley@rpc.aphp.fr
Abstract:
Sodium oxybate (GHB, Xyrem, Jazz Pharmaceuticals) is used to treat cataplexy in patients with narcolepsy. We report the case of a middle aged, normo-ponderal narcoleptic woman without risk factors who developed reversible sleep apnea and objective sleepiness when treated by sodium oxybate, with an apnea-hypopnea index (AHI) of 19.7 on sodium oxybate and AHI 4.8 without treatment. Despite a subjective improvement in vigilance, mean sleep latency on MWT decreased from 21 minutes to 8 minutes on sodium oxybate.
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