Chronic cough and OSA: a new association?
Krishna M Sundar1, Sarah E Daly
1Department of Medicine, Utah Valley Pulmonary Clinic, Provo, UT 84604, USA. Krishna.sundar@imail.org
Summary
Chronic cough lasting over two months may be linked to obstructive sleep apnea (OSA). Treating OSA can resolve chronic cough by reducing airway inflammation and improving related conditions like GERD, CVA, and UACS.
Area of Science:
- Pulmonology
- Sleep Medicine
- Gastroenterology
Background:
- Chronic cough, defined as lasting >2 months, often remains unexplained despite addressing common causes like GERD, CVA, and UACS.
- Current diagnostic guidelines for chronic cough rely on therapeutic trials for suspected GERD, CVA, and UACS.
- A significant portion of chronic cough cases remain refractory to standard diagnostic and treatment approaches.
Observation:
- Recent findings suggest chronic cough resolution after treating obstructive sleep apnea (OSA).
- The relationship between OSA and chronic cough, including its common causes, requires further investigation.
- This review explores potential pathophysiological links between OSA and GERD, UACS, and CVA.
Findings:
- OSA may share pathophysiological mechanisms with common causes of chronic cough.
- Airway inflammation, a known trigger for cough, is discussed in relation to OSA.
- Continuous positive airway pressure (CPAP) therapy for OSA may resolve cough by reducing airway inflammation.
Implications:
- Investigating OSA as a potential underlying cause of chronic cough is warranted.
- Understanding the link between OSA and cough may lead to novel therapeutic strategies.
- This review highlights the importance of considering sleep-disordered breathing in unexplained chronic cough.
Keywords:
Chronic coughairway inflammationgastroesophageal reflux diseaseobstructive sleep apneaupper airway cough syndromeMore Related Videos
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