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Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
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Biophysical and structural considerations for protein sequence evolution.

Johan A Grahnen1, Priyanka Nandakumar, Jan Kubelka

  • 1Department of Molecular Biology, University of Wyoming, Laramie, WY 82071, USA.

BMC Evolutionary Biology
|December 17, 2011
PubMed
Summary

Protein sequence evolution models must account for biophysics. A new physics-based model and an informational model both deviate from native sequences, highlighting the need for improved protein folding and binding function representations in evolutionary studies.

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