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Related Concept Videos

Transdermal Drug Delivery Systems01:18

Transdermal Drug Delivery Systems

Transdermal drug delivery systems (TDDS) enable the controlled release of drugs across the skin into systemic circulation. They are particularly advantageous for drugs with short half-lives or narrow therapeutic indices, as they maintain consistent plasma concentrations and reduce the risk of subtherapeutic or toxic levels.TDDS are categorized into monolithic, reservoir, and mixed systems. Monolithic systems embed the drug in a polymer matrix, where diffusion governs release. Reservoir systems...
Modified-Release Drug Delivery Systems: Influencing Factors01:20

Modified-Release Drug Delivery Systems: Influencing Factors

Modified-release drug delivery systems are designed to optimize the therapeutic effect of drugs by minimizing side effects, reducing the dosage required, and controlling drug release to align with pharmacokinetic and pharmacodynamic needs. The system depends on two key factors: the drug's release from the formulation and its movement through the body to the target site. Unlike conventional dosage forms, where absorption is the limiting step, the rate of drug release is the key determinant in...
Drug Delivery: Overview01:16

Drug Delivery: Overview

The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the gastrointestinal...
Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.

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Dissolving Microneedle Array Patches Manufactured By Solvent Casting Technique and Essential Characterization of Microneedle-Based Biomedical Devices
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Adhesive properties: a critical issue in transdermal patch development.

Francesco Cilurzo1, Chiara G M Gennari, Paola Minghetti

  • 1Università degli Studi di Milano, Department of Pharmaceutical Science, Via G. Colombo, 71-20131, Milano, Italy. francesco.cilurzo@unimi.it

Expert Opinion on Drug Delivery
|December 17, 2011
PubMed
Summary
This summary is machine-generated.

Transdermal patch adhesion is crucial for therapeutic efficacy and safety. This review details methods for measuring tack, shear, and peel adhesion, essential for quality control and regulatory evaluation of medicated plasters.

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Area of Science:

  • Pharmaceutical Sciences
  • Materials Science
  • Dermatology

Background:

  • Transdermal patches and medicated plasters are established prolonged-release dosage forms.
  • Skin adhesion is critical for therapeutic efficacy and safety.
  • Failures in patch adhesion are frequently reported to regulatory agencies.

Purpose of the Study:

  • To review methods for measuring adhesive properties of transdermal patches.
  • To discuss the influence of formulation on adhesion.
  • To explore the relationship between in vitro adhesion and in vivo performance.

Main Methods:

  • Description of widely used methods for assessing tack, shear, and peel adhesion.
  • Discussion of quality control procedures for patches.
  • Analysis of how formulation variables impact adhesive properties.

Main Results:

  • Adhesive properties are defined by tack, shear adhesion, and peel adhesion.
  • Formulative variables significantly influence these adhesive properties.
  • Understanding these relationships is key to predicting in vivo performance.

Conclusions:

  • Pharmacopoeias should consider compendial testing for adhesive patch properties.
  • Regulatory agencies need to establish guidelines for evaluating patch adhesion during development.
  • Standardized testing is essential for ensuring patch efficacy and safety.