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[Effects of bacillus bifidus supplementation on the immunity in very-low-birth-weight infants]

Hai-Juan Zhu1, Yan Cai

  • 1Department of Neonatology, Suzhou Municipal Hospital, Suzhou, Jiangsu 215002, China. zhuhj777@sina.com

Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics
|December 17, 2011
PubMed

Insights

Bacillus bifidus supplementation improved gastrointestinal symptoms and boosted immunity in very-low-birth-weight (VLBW) infants. This study highlights the benefits of probiotics for infant health.

Area of Science:

  • Neonatal immunology
  • Microbiome research
  • Pediatric nutrition

Background:

  • Very-low-birth-weight (VLBW) infants are susceptible to gastrointestinal issues and immune deficiencies.
  • Early life microbial colonization plays a crucial role in immune system development.

Purpose of the Study:

  • To investigate the impact of Bacillus bifidus supplementation on the immune status of VLBW infants.
  • To assess the effect of Bacillus bifidus on clinical and immunological parameters in VLBW infants.

Main Methods:

  • A randomized controlled trial involving 50 VLBW infants in a neonatal intensive care unit.
  • The intervention group received Bacillus bifidus for 14 days alongside standard care.
  • Immunological markers (T lymphocyte subsets, immunoglobulins) and clinical outcomes were monitored.

Main Results:

  • Bacillus bifidus supplementation reduced the need for brine enemas in VLBW infants.
  • A significant increase in CD4(+) T lymphocytes and the CD4(+)/CD8(+) ratio was observed.
  • Elevated levels of immunoglobulin A were found in the peripheral blood of supplemented infants.

Conclusions:

  • Bacillus bifidus supplementation demonstrates a positive effect on the immune system of VLBW infants.
  • Probiotic intervention can help improve gastrointestinal symptoms in this vulnerable population.
Abstract

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