Related Experiment Video
Updated: May 26, 2026

Synergetic Use of Neural Precursor Cells and Self-assembling Peptides in Experimental Cervical Spinal Cord Injury
Published on: February 23, 2015
SDF-1/CXCL12: its role in spinal cord injury
Anne Jaerve1, Frank Bosse, Hans Werner Müller
1Molecular Neurobiology Laboratory, Department of Neurology, Heinrich-Heine-University, Medical Faculty, Moorenstr. 5, 40225 Düsseldorf, Germany.
Abstract:
The chemokine stromal cell-derived factor 1 (SDF-1/CXCL12), is not only the most ancient, but also one of the most potent chemotactic factors. Orchestrating the migration of cells as well as promoting axon outgrowth in the presence of myelin inhibitors, SDF-1 is fundamental to central nervous system development, homeostasis and traumatic injury. SDF-1 attracts endogenous stem/precursor cells and immune cells to the injury site and, upon local infusion, enhances axonal sprouting following spinal cord injury. Together these features make SDF-1 a very exciting molecule for spinal cord repair.
More Related Videos
Related Concept Videos
Spinal Cord Injury ll: Pathophysiology
Secondary Spinal Cord Injury llI: Pathophysiology

