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Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
The Functions of the Skeletal System01:22

The Functions of the Skeletal System

The most apparent functions of the skeletal system are support, protection, and movement. However, bone tissue also performs several other critical metabolic functions. For one, the bone matrix acts as a reservoir for a number of minerals important to the functioning of the body, especially calcium and phosphorus. These minerals, present in the bone tissue, can be released back into the bloodstream when required. Calcium ions, for example, are essential for muscle contractions and controlling...
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...

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Cantilever Bending of Murine Femoral Necks
06:44

Cantilever Bending of Murine Femoral Necks

Published on: January 5, 2022

[Pathophysiology of aging bone].

Sergio Portal-Núñez1, Daniel Lozano, Mónica de la Fuente

  • 1Laboratorio de Metabolismo Mineral y Óseo, Instituto de Investigación Sanitaria-Fundación Jiménez Díaz, Madrid, España. sportal@fjd.es

Revista Espanola De Geriatria Y Gerontologia
|December 17, 2011
PubMed
Summary
This summary is machine-generated.

Aging leads to bone loss and increased fracture risk due to metabolic changes in bone tissue. This review summarizes studies on the physiological and molecular basis of age-related bone alterations.

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Trabecular Bone Microarchitecture Evaluation in an Osteoporosis Mouse Model
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Last Updated: May 26, 2026

Cantilever Bending of Murine Femoral Necks
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Cantilever Bending of Murine Femoral Necks

Published on: January 5, 2022

Trabecular Bone Microarchitecture Evaluation in an Osteoporosis Mouse Model
06:59

Trabecular Bone Microarchitecture Evaluation in an Osteoporosis Mouse Model

Published on: September 8, 2023

Area of Science:

  • Gerontology and Bone Biology
  • Metabolic and Molecular Mechanisms

Context:

  • Aging is characterized by a decline in organ function, significantly impacting bone health.
  • Age-related bone loss increases susceptibility to fractures, a major health concern in older populations.

Purpose:

  • To review and synthesize current research on the physiological and molecular mechanisms underlying age-related bone alterations.
  • To consolidate knowledge derived from animal models and cell cultures regarding bone aging.

Summary:

  • Aging affects bone mass and quality, contributing to increased fracture risk.
  • Metabolic changes within bone tissue are key factors in age-related bone deterioration.
  • Existing research, primarily from animal models and cell cultures, provides insights into these mechanisms.

Impact:

  • Establishes a foundation for understanding age-related bone diseases like osteoporosis.
  • Highlights the need for further research into the specific molecular pathways involved in bone aging.
  • Informs potential therapeutic strategies targeting age-related bone loss.