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Migraine and stroke: a complex association with clinical implications
Tobias Kurth1, Hugues Chabriat, Marie-Germaine Bousser
1Inserm Unit 708-Neuroepidemiology, University of Bordeaux, Bordeaux, France.
The Lancet. Neurology
|December 17, 2011
Summary
Migraine with aura, unlike migraine without aura, doubles the risk of ischemic stroke. Further research is needed to determine if this increased stroke risk is primarily due to migraine with aura or secondary to other conditions.
Area of Science:
- Neurovascular disorders
- Headache medicine
- Stroke neurology
Background:
- Migraine and stroke are complex neurovascular conditions.
- Migraine without aura is common and not strongly linked to stroke.
- Migraine with aura presents a significantly increased risk of ischemic stroke.
Purpose of the Study:
- To investigate the relationship between migraine with aura and ischemic stroke risk.
- To explore the underlying mechanisms potentially linking migraine with aura to stroke.
- To differentiate the stroke risk associated with primary migraine with aura versus secondary causes.
Main Methods:
- Review of epidemiological data on migraine and stroke.
- Analysis of the pathophysiology of cortical spreading depression in migraine with aura.
- Examination of comorbid conditions that may influence stroke risk in migraine patients.
Main Results:
- A confirmed doubling of ischemic stroke risk in individuals with migraine with aura.
- Cortical spreading depression in migraine with aura can be triggered by various factors.
- Some triggers for cortical spreading depression are independent risk factors for ischemic stroke.
Conclusions:
- Migraine with aura is associated with a substantially elevated risk of ischemic stroke.
- The increased stroke risk may be influenced by underlying conditions or the primary headache disorder itself.
- Further investigation is required to clarify the causal relationship and contributing factors.
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