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What is the Immune System?01:38

What is the Immune System?

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Updated: May 26, 2026

Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NF&#954;B Activity and Breast Cancer Stem Cells
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Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NFκB Activity and Breast Cancer Stem Cells

Published on: January 18, 2017

Aspirin and immune system.

Muzammal Hussain1, Aqeel Javeed, Muhammad Ashraf

  • 1Department of Pharmacology & Toxicology, University of Veterinary and Animal Sciences, Lahore, Pakistan.

International Immunopharmacology
|December 17, 2011
PubMed
Summary
This summary is machine-generated.

Aspirin, a trusted therapeutic, modulates immune cells like dendritic cells and T cells, revealing its potential for immune tolerance and treating autoimmune diseases. This research highlights aspirin's immunoregulatory effects.

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Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NF&#954;B Activity and Breast Cancer Stem Cells
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Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination
09:38

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination

Published on: September 12, 2016

Area of Science:

  • Immunology and Pharmacology
  • Therapeutic Drug Action

Background:

  • Aspirin is a globally recognized therapeutic agent with established anti-inflammatory properties.
  • Emerging research indicates aspirin's significant role in immune cell function and immunopathology.

Purpose of the Study:

  • To explore aspirin's immunomodulatory effects on various immune cells.
  • To outline the clinical potential of aspirin in immune tolerance and autoimmune conditions.

Main Methods:

  • Review of existing literature on aspirin's interaction with immune cells.
  • Analysis of aspirin's impact on dendritic cells, T cells, neutrophils, macrophages, NK cells, and lymphocytes.

Main Results:

  • Aspirin induces tolerogenic activity in dendritic cells.
  • Aspirin promotes naive T cells to adopt regulatory phenotypes, suggesting immunoregulatory capabilities.
  • Aspirin influences both innate and adaptive immune responses.

Conclusions:

  • Aspirin exhibits significant immunomodulatory properties, impacting key immune cells.
  • Clinical applications for aspirin in immune tolerance, autoimmunity, and allograft rejection are promising.