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Opportunistic posttransplantation virus infections in renal transplant recipients

J H Hu1, H Zhao, Y P Huang

  • 1State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.

Transplantation Proceedings
|December 17, 2011
PubMed
Abstract

Insights

JC virus (JCV) and Cytomegalovirus (CMV) infections are common in renal transplant (RT) recipients. Cyclosporine (CsA) is a risk factor for both, and CMV infection increases JCV risk.

Area of Science:

  • Nephrology
  • Virology
  • Immunology

Background:

  • Opportunistic viral infections, including Cytomegalovirus (CMV) and BK virus (BKV), are significant complications in renal transplant (RT) recipients.
  • Limited data exists on JC virus (JCV) infection and its interplay with CMV in this patient population.

Purpose of the Study:

  • To investigate the incidence rates of JCV and CMV infections in RT recipients.
  • To identify risk factors associated with these viral infections.
  • To explore the correlation between JCV and CMV infections.

Main Methods:

  • A prospective study involving 52 RT recipients.
  • Detection of JCV and CMV in urine samples using nested qualitative polymerase chain reaction (PCR).
  • Analysis of clinical characteristics and risk factors using binary logistic regression.

Main Results:

  • JCV and CMV were detected in 40.4% and 34.6% of RT recipients, respectively.
  • Cyclosporine (CsA) emerged as a significant risk factor for both JCV and CMV infections (OR 7.187 for JCV, OR 4.182 for CMV).
  • CMV infection was identified as a risk factor for JCV infection (OR 3.900).

Conclusions:

  • JCV and CMV infections are prevalent in renal transplant recipients.
  • Cyclosporine (CsA) is a key risk factor contributing to both JCV and CMV infections.
  • A significant relationship exists between CMV infection and the development of JCV infection in this cohort.

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