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Single-port Non-liposuction Endoscopic Axillary Lymph Node Dissection in Breast Cancer Surgery
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Body mass index is associated with higher lymph node counts during retroperitoneal lymph node dissection.

R Houston Thompson1, Brett S Carver, George J Bosl

  • 1Department of Surgery-Urology Service, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

Urology
|December 17, 2011
PubMed
Summary

Body Mass Index (BMI) is linked to higher lymph node counts in patients undergoing retroperitoneal lymph node dissection (RPLND). This finding is crucial for assessing the adequacy of lymph node dissections in cancer treatment.

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Area of Science:

  • Urology
  • Surgical Oncology
  • Cancer Research

Background:

  • Lymph node counts are a proposed quality assurance measure in cancer surgery.
  • Factors influencing lymph node counts, particularly patient characteristics like BMI, require further investigation.

Purpose of the Study:

  • To investigate the association between Body Mass Index (BMI) and lymph node counts in patients undergoing primary retroperitoneal lymph node dissection (RPLND).

Main Methods:

  • Retrospective analysis of 255 patients from the Memorial Sloan-Kettering Testis Cancer Database (1999-2008) treated with primary RPLND for nonseminomatous germ cell tumors.
  • Linear regression models (univariate and multivariable) were used to assess the association between BMI and total lymph node counts, adjusting for surgical year, stage, and surgeon volume.

Main Results:

  • Median BMI was 26.1, with median lymph node count of 38.
  • Higher BMI was significantly associated with increased lymph node counts in both univariate (P=.026) and multivariable analyses (P=.009).
  • Other factors associated with higher node counts included high-volume surgeon, pathologic stage, and more recent year of surgery.

Conclusions:

  • Body Mass Index (BMI) is independently associated with higher lymph node counts in patients undergoing RPLND.
  • These findings may have implications for using lymph node counts as a surrogate marker for the adequacy of lymph node dissection.