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Vaccines targeting drugs of abuse: is the glass half-empty or half-full?
Kim D Janda1, Jennifer B Treweek
1Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, BCC 582, La Jolla, California 92037-1000, USA. kdjanda@scripps.edu
Abstract:
The advent of vaccines targeting drugs of abuse heralded a fundamentally different approach to treating substance-related disorders. In contrast to traditional pharmacotherapies for drug abuse, vaccines act by sequestering circulating drugs and terminating the drug-induced 'high' without inducing unwanted neuromodulatory effects. Drug-targeting vaccines have entered clinical evaluation, and although these vaccines show promise from a biomedical viewpoint, the ethical and socioeconomic implications of vaccinating patients against drugs of abuse merit discussion within the scientific community.
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