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Operating and Biocontainment Procedures of a Facility for Laboratory Mice with a Natural Microbiome: Immunophenotyping Procedure

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Of mice and microflora: considerations for genetically engineered mice.

P M Treuting¹, C B Clifford, R S Sellers

¹Department of Comparative Medicine & Histology and Imaging Core, School of Medicine, University of Washington, T140 Health Science Center, Box 357190, Seattle, WA 98195-7190, USA. treuting@uw.edu

Veterinary Pathology

|December 17, 2011

Summary

Mouse microflora significantly influences genetically engineered mouse (GEM) phenotypes. Understanding these host-microbe interactions is crucial for accurate research and developing new disease models.

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Area of Science:

Microbiology
Genetics
Immunology

Background:

Genetically engineered mouse (GEM) phenotypes result from genetic, environmental, and microflora interactions.
Host-microbe interactions, often overlooked, can lead to novel model systems and microbial discoveries.
Historically, research focused on disease-causing microbes, but GEMs reveal previously unknown agents.

Purpose of the Study:

To illustrate how microflora impacts GEM phenotypes.
To highlight infectious diseases in GEM colonies.
To review underappreciated microbial agents affecting mouse models.

Main Methods:

Review of infectious diseases in GEM colonies.
Analysis of host-microbe interactions in GEMs.
Literature review of relevant microbial agents.

Main Results:

Microflora plays a critical role in shaping GEM phenotypes.
GEMs have revealed novel microbial agents impacting research.
Understanding microflora is essential for interpreting GEM data.

Conclusions:

Microflora is a key determinant of GEM phenotypes.
Host-microbe interactions are vital for translational research using GEM models.
Further investigation into microflora's role is necessary for advancing biomedical research.