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Related Concept Videos

Data Reporting and Recording01:24

Data Reporting and Recording

Reporting and recording are crucial in data documentation. The timely, thorough, and accurate documentation of facts is essential when recording patient data. Failure to record findings during an assessment or interpretation of a problem will result in loss of information and make the patient document unreliable. The reader is left with general impressions if the information is not specific. A recording is documenting data of the individual's health information in a traceable, secure, and...
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IP3/DAG Signaling Pathway01:11

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Membrane lipids such as phosphatidylinositol (PI) are precursors for several membrane-bound and soluble second messengers. Specific kinases phosphorylate PI and produce phosphorylated inositol phospholipids. One such inositol phospholipids are the  phosphatidylinositol-4,5 bisphosphate [PI(4,5)P2], present in the inner half of the lipid bilayer. Upon ligand binding, GPCR stimulates Gq proteins to turn on phospholipase Cꞵ. Activated phospholipase Cꞵ cleaves PI(4,5)P2 and produces two-second...
GTPases and their Regulation02:14

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Guanine nucleotide-binding proteins (G-proteins), also known as GTPases, are a superfamily of proteins that regulate many cellular processes, such as cell signaling, vesicular transport, and the regulation of cell shape and motility. Mutation or dysfunction of these proteins can lead to disease. There are around 40,000 known G-proteins that can broadly be classified into two groups ‒  small G-proteins consisting of a single domain and large multi-domain G-proteins.
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GTPases and their Regulation

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Related Experiment Video

Updated: May 26, 2026

Generation of Comprehensive Thoracic Oncology Database - Tool for Translational Research
11:18

Generation of Comprehensive Thoracic Oncology Database - Tool for Translational Research

Published on: January 22, 2011

dbGaP data access requests: a call for greater transparency.

Lorelei Walker1, Helene Starks, Kathleen M West

  • 1Institute for Public Health Genetics, University of Washington, Seattle, WA 98195, USA.

Science Translational Medicine
|December 17, 2011
PubMed
Summary
This summary is machine-generated.

Mandatory data sharing through the National Center for Biotechnology Information database of genotypes and phenotypes (dbGaP) supports broad secondary research. However, tracking translational benefits from this data sharing remains challenging due to public reporting limitations.

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Last Updated: May 26, 2026

Generation of Comprehensive Thoracic Oncology Database - Tool for Translational Research
11:18

Generation of Comprehensive Thoracic Oncology Database - Tool for Translational Research

Published on: January 22, 2011

Area of Science:

  • Biomedical Informatics
  • Genomics
  • Public Health

Background:

  • Demonstrating the value of mandatory data-sharing mechanisms is crucial for scientific and public health advancement.
  • The U.S. National Center for Biotechnology Information database of genotypes and phenotypes (dbGaP) is a key resource for genomic data sharing.

Purpose of the Study:

  • To evaluate the extent and scope of secondary research enabled by dbGaP data access.
  • To identify limitations in current public reporting that hinder the assessment of translational benefits.

Main Methods:

  • Manual review of 2724 data access requests approved by dbGaP between June 2007 and August 2010.
  • Analysis of investigator affiliations (academic, governmental, nonprofit, for-profit) and geographic origin.

Main Results:

  • dbGaP facilitates a diverse range of secondary research across various institutional types and international collaborations.
  • Approved data access requests originated from academic, governmental, and commercial entities globally.
  • Significant limitations exist in public reporting, preventing the clear tracing of research outcomes to long-term translational impact.

Conclusions:

  • dbGaP effectively supports widespread secondary data analysis, contributing to scientific discovery.
  • Enhanced public reporting mechanisms are needed to fully realize and demonstrate the translational value of shared genomic data.