Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Preclinical Models of Rare Corneal and Ocular Surface Diseases: a Comprehensive Narrative Review.

Ophthalmology and therapy·2026
Same author

Correction: Mesentier-Louro et al. Time-Dependent Nerve Growth Factor Signaling Changes in the Rat Retina During Optic Nerve Crush-Induced Degeneration of Retinal Ganglion Cells. <i>Int. J. Mol. Sci.</i> 2017, <i>18</i>, 98.

International journal of molecular sciences·2026
Same author

A Multicenter, Real-World Experience with Polyhexamethylene Biguanide (PHMB) 0.08% Monotherapy for Treating Acanthamoeba Keratitis: A Retrospective Review of 39 Cases.

Ophthalmology and therapy·2026
Same author

The Role of Innervation in Ocular Surface Homeostasis, Tissue Remodeling Following Nerve Injury, and the Therapeutic Potential of Hemocomponents in Neuronal and Cicatricial Pathologies.

Journal of clinical medicine·2026
Same author

The Impact of Aging and Sex on Corneal Nerve Density and Function.

Investigative ophthalmology & visual science·2026
Same author

Congenital aniridia: European COST action ANIRIDIA-NET guidelines for diagnosis, management and care.

Acta ophthalmologica·2025

Related Experiment Video

Updated: May 26, 2026

Quantification of Acanthamoeba spp. Motility
07:33

Quantification of Acanthamoeba spp. Motility

Published on: September 20, 2024

Double-biguanide therapy for resistant acanthamoeba keratitis.

Giulio Ferrari1, Stanislav Matuska, Paolo Rama

  • 1Bietti Eye Foundation, Rome, Italy.

Case Reports in Ophthalmology
|December 17, 2011
PubMed
Summary

Acanthamoeba keratitis resistant to standard treatments was successfully managed with a combination of polyhexamethylene biguanide (PHMB) and chlorhexidine. This novel therapy offers a new option for drug-resistant cases.

Keywords:
Acanthamoeba keratitisBiguanideDiamidine

Related Experiment Videos

Last Updated: May 26, 2026

Quantification of Acanthamoeba spp. Motility
07:33

Quantification of Acanthamoeba spp. Motility

Published on: September 20, 2024

Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Microbiology

Background:

  • Acanthamoeba keratitis (AK) is a severe microbial infection of the cornea.
  • Drug resistance in AK poses significant clinical challenges, limiting treatment options.

Observation:

  • A 39-year-old woman presented with a corneal ulcer due to Acanthamoeba keratitis.
  • The infection was resistant to conventional treatments including polyhexamethylene biguanide (PHMB)-hexamidine and chlorhexidine-hexamidine.

Findings:

  • Successful treatment was achieved using an association therapy of PHMB and chlorhexidine.
  • The patient's visual acuity improved to 20/20 after perforating keratoplasty, with no recurrence at 7 months.

Implications:

  • This case highlights the diverse presentations of drug resistance in Acanthamoeba infections.
  • PHMB-chlorhexidine combination therapy may be a viable alternative for recalcitrant AK cases.