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Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...

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Tropomodulin 3 Overexpression as a Marker for Platinum Resistance and Immune Infiltration in Ovarian Cancer
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Tropomodulin 3 Overexpression as a Marker for Platinum Resistance and Immune Infiltration in Ovarian Cancer

Published on: August 2, 2024

MicroRNA expression characterizes oligometastasis(es).

Yves A Lussier1, H Rosie Xing, Joseph K Salama

  • 1Comprehensive Cancer Center, University of Chicago, Chicago, Illinois, United States of America. ylussier@uic.edu

Plos One
|December 17, 2011
PubMed
Summary
This summary is machine-generated.

Oligometastasis, an intermediate cancer state, may benefit from targeted therapy. MicroRNA-200 family expression predicts progression, aiding patient selection for metastasis-directed treatments.

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miRNA Expression Analyses in Prostate Cancer Clinical Tissues
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miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

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Last Updated: May 26, 2026

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09:40

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Published on: August 2, 2024

miRNA Expression Analyses in Prostate Cancer Clinical Tissues
11:29

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Cancer staging traditionally divides disease into localized or metastatic.
  • Oligometastasis is proposed as an intermediate state with ≤ 5 metastases.
  • Identifying predictors of progression from oligometastasis to polymetastasis is crucial for treatment selection.

Purpose of the Study:

  • To identify microRNA expression patterns in oligometastatic patients.
  • To find predictors of progression from oligometastasis to polymetastasis.
  • To explore the biological basis of oligometastasis and its progression.

Main Methods:

  • Analysis of microRNA expression in tumor samples from oligometastatic patients treated with radiotherapy.
  • Development of an oligometastatic-polymetastatic xenograft model.
  • Experimental enhancement of microRNA-200c in an oligometastatic cell line.

Main Results:

  • A microRNA classifier, including the microRNA-200 family, identified patients who did not progress to polymetastasis.
  • Patient-derived microRNAs in a xenograft model distinguished between oligometastatic and polymetastatic outcomes.
  • Enhancing microRNA-200c in an oligometastatic cell line induced polymetastatic progression.

Conclusions:

  • MicroRNA expression patterns provide a biological basis for understanding oligometastasis.
  • MicroRNA expression analysis can potentially identify patients likely to remain oligometastatic.
  • This finding may improve patient selection for metastasis-directed therapies.