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ABO Incompatible Kidney Transplantation-Current Status and Uncertainties
1Division of Transplant Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, No. 50 Ilwon-dong, Kangnam-ku, Seoul 135-710, Republic of Korea.
Journal of Transplantation
|December 17, 2011
Summary
ABO incompatible kidney transplantation is now successful due to advances in desensitization protocols. This review covers the history, outcomes, and immunological aspects of ABO incompatible kidney transplants.
Area of Science:
- Nephrology
- Immunology
- Transplantation
Background:
- ABO blood group incompatibility historically precluded kidney transplantation.
- Recent advancements enable successful ABO incompatible kidney transplants.
Purpose of the Study:
- To review the history and outcomes of ABO incompatible kidney transplantation.
- To describe desensitization protocols and immunologic surveillance.
- To explain mechanisms of antibody-mediated injury and accommodation.
Main Methods:
- Literature review of ABO incompatible kidney transplantation.
- Analysis of desensitization modalities and protocols.
- Discussion of immunologic surveillance and rejection mechanisms.
Main Results:
- ABO incompatible kidney transplantation is increasingly successful.
- Defined desensitization practices improve outcomes.
- Understanding of immunologic mechanisms is crucial.
Conclusions:
- ABO incompatible kidney transplantation is a viable option.
- Effective desensitization and surveillance are key to success.
- Further research into accommodation and injury mechanisms is warranted.
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