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Related Experiment Videos

Sensitization versus tolerance to haloperidol-induced catalepsy: multiple determinants.

D E Barnes1, B Robinson, J G Csernansky

  • 1Department of Veterans Affairs, Laboratory of Clinical Psychopharmacology, Palo Alto, CA 94304.

Pharmacology, Biochemistry, and Behavior
|August 1, 1990
PubMed
Summary

Rats developed tolerance to haloperidol-induced catalepsy only under specific daily dosing and testing conditions. However, sensitization to haloperidol was more common, influenced by dose, frequency, and testing methods.

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Behavioral Science

Background:

  • Haloperidol is a typical antipsychotic used to treat psychosis.
  • Understanding tolerance and sensitization to its effects is crucial for treatment efficacy.
  • Catalepsy is a motor side effect of haloperidol.

Purpose of the Study:

  • To investigate how dose, administration frequency, and testing conditions affect tolerance and sensitization to haloperidol-induced catalepsy in rats.
  • To determine the conditions under which tolerance or sensitization develops.

Main Methods:

  • Rats received daily or weekly subcutaneous injections of haloperidol (0.05-5.00 mg/kg) for up to 22 days.
  • Catalepsy was assessed using the horizontal bar and inclined screen tests, with single or repeated measurements.

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  • Experimental variables included drug dose, administration schedule (daily/weekly), and testing frequency.

    • Main Results:

    • Tolerance to haloperidol-induced catalepsy was observed only in rats treated daily with 1.5 mg/kg and tested repeatedly on the horizontal bar.
    • Sensitization was more broadly observed across various doses, administration schedules, and testing methods.
    • Sensitization was most pronounced with weekly administration and repeated horizontal bar testing.

    Conclusions:

    • The development of tolerance versus sensitization to haloperidol-induced catalepsy is highly dependent on experimental parameters.
    • No single variable consistently predicted tolerance or sensitization.
    • Dose, administration schedule, and behavioral testing conditions critically influence the long-term effects of haloperidol on catalepsy.