Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Neurogenesis and Regeneration of Nervous Tissue

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...

Stem Cell Therapy for Tissue Regeneration

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...

Tissue Renewal without Stem Cells

Tissue Renewal without Stem Cells

After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...

Renewal of Intestinal Stem Cells

Renewal of Intestinal Stem Cells

The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the goblet,...

Stem Cell Niche

Stem Cell Niche

The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...

Aging

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Development of a Humanized Anti-Fibrotic Antibody Targeting Extracellular Collagen Assembly to Reduce Post-Traumatic Scarring.

bioRxiv : the preprint server for biology·2026

Same author

Simulated Workflow Feasibility Evaluation of a Web-Based Periorbital Measurement Platform: Development and Usability Study.

JMIR human factors·2026

Same author

Alternate splicing converts human CD137 from costimulatory to immunosuppressive function.

Journal of autoimmunity·2025

Same author

Seroprevalence of dengue virus infection among febrile patients visiting healthcare facilities in the selected districts of Afar region, Northeast Ethiopia.

BMC infectious diseases·2025

Same author

Higher order receptor clustering due to the IgG3 subclass is necessary for TLR4 signaling and tolerance induction by novel human anti-TLR4 antibodies.

mAbs·2025

Same author

Neutralization of Marinobufagenin Demonstrates Efficacy In Vitro and In Vivo in Models of Pre-Eclampsia.

Biomedicines·2025

Search research articles

Related Experiment Video

Updated: May 26, 2026

Growing Neural Stem Cells from Conventional and Nonconventional Regions of the Adult Rodent Brain

Growing Neural Stem Cells from Conventional and Nonconventional Regions of the Adult Rodent Brain

Published on: November 18, 2013

Overcoming the aging systemic milieu to restore neural stem cell function.

Andrew R Mendelsohn¹, James W Larrick

¹Panorama Research Institute, 1230 Bordeaux DriveSunnyvale, CA 94089, USA. amend@regensci.org

Rejuvenation Research

|December 20, 2011

Summary

Aging reduces brain cell generation and cognitive function due to circulating factors. The chemokine CCL11/eotaxin increases with age, inhibiting neurogenesis and stem cell function.

More Related Videos

Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling

Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling

Published on: May 31, 2017

High Throughput Characterization of Adult Stem Cells Engineered for Delivery of Therapeutic Factors for Neuroprotective Strategies

High Throughput Characterization of Adult Stem Cells Engineered for Delivery of Therapeutic Factors for Neuroprotective Strategies

Published on: January 4, 2015

Related Experiment Videos

Last Updated: May 26, 2026

Growing Neural Stem Cells from Conventional and Nonconventional Regions of the Adult Rodent Brain

Growing Neural Stem Cells from Conventional and Nonconventional Regions of the Adult Rodent Brain

Published on: November 18, 2013

Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling

Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling

Published on: May 31, 2017

High Throughput Characterization of Adult Stem Cells Engineered for Delivery of Therapeutic Factors for Neuroprotective Strategies

High Throughput Characterization of Adult Stem Cells Engineered for Delivery of Therapeutic Factors for Neuroprotective Strategies

Published on: January 4, 2015

Area of Science:

Neuroscience
Aging Biology
Stem Cell Research

Background:

Mammalian aging is characterized by declining neurogenesis and cognitive function.
Systemic factors circulating in the blood are implicated in age-related neurogenesis inhibition.
Previous studies suggest transforming growth factor-beta (TGF-β) impairs satellite cell repair.

Purpose of the Study:

To identify specific circulating factors responsible for age-related decline in neurogenesis.
To investigate the role of chemokine CCL11/eotaxin in inhibiting neural stem cell function.
To explore therapeutic targets for mitigating age-associated stem cell dysfunction.

Main Methods:

Cross-circulation experiments connecting young and old mice to assess systemic factor effects.
Administration of chemokine CCL11/eotaxin to young mice to evaluate its impact on neurogenesis.
Analysis of stem cell function in the context of aging systemic milieu.

Main Results:

Connecting old and young mice revealed that systemic factors influence neurogenesis rates.
Elevated levels of chemokine CCL11/eotaxin in aging were identified as an inhibitor of neurogenesis.
CCL11/eotaxin's inhibitory effect on neurogenesis in young mice was likely mediated by CCR3 receptors on neural stem cells.

Conclusions:

The systemic environment significantly impacts the aging of adult stem cells.
Chemokine CCL11/eotaxin is a key factor contributing to age-related stem cell dysfunction and reduced neurogenesis.
Targeting specific systemic factors like CCL11 offers a promising therapeutic strategy for age-related functional decline.