Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Ischemic Stroke l: Introduction

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.

Ischemic Stroke ll: Pathophysiology

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...

Depressive Disorders: MDD and Dysthymia

Depressive Disorders: MDD and Dysthymia

Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...

Hemorrhagic Stroke ll: Pathophysiology

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...

Depressive Disorders: Etiology

Depressive Disorders: Etiology

Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...

Hemorrhagic Stroke l: Introduction

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Network analysis of NRG1 variants of uncertain significance (VUSes) in advanced non-small-cell lung cancer and their prognostic role in EGFR-mutant patients treated with first-line osimertinib.

ESMO open·2025

Same author

A commentary on 'Focal vibration in dysphagia: A technological treatment for severe acquired brain injury rehabilitation'.

Journal of oral rehabilitation·2023

Same author

500 EFFECTS OF COVID-19 PANDEMICS ON SYMPTOMS AND QUALITY OF LIFE IN PATIENTS AFFECTED BY INTERSTITIAL CYSTITIS/PAINFUL BLADDER SYNDROME (IC/PBS) AND IRRITABLE BOWEL SYNDROME (IBS).

Continence (Amsterdam, Netherlands)·2022

Same author

Gut-oriented interventions in patients with multiple sclerosis: fact or fiction?

European review for medical and pharmacological sciences·2022

Same author

The role of the Sapienza GLObal Bedside Evaluation of Swallowing after Stroke (GLOBE-3S) in the prevention of stroke-associated pneumonia (SAP).

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2021

Same author

Transradial Neuroendovascular Procedures in Adolescents: Initial Single-Center Experience.

AJNR. American journal of neuroradiology·2021

Search research articles

Related Experiment Video

Updated: May 26, 2026

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

Published on: May 22, 2019

Depression after minor stroke: prevalence and predictors.

M Altieri¹, I Maestrini, A Mercurio

¹Clinica Neurologica A, Department of Neurology and Psychiatry, Viale dell'Università, Rome, Italy. marta.altieri@uniroma1.it

European Journal of Neurology

|December 20, 2011

Summary

Post-stroke depression (PSD) is common, even in minor stroke patients. Early detection of depressive symptoms like crying and guilt can help predict long-term PSD development.

More Related Videos

Effect of Yi-Nao-Jie-Yu Prescription on Post-Stroke Depression in Rats using Middle Cerebral Artery Occlusion Combined with Behavioral Restraint

Effect of Yi-Nao-Jie-Yu Prescription on Post-Stroke Depression in Rats using Middle Cerebral Artery Occlusion Combined with Behavioral Restraint

Published on: January 9, 2026

Related Experiment Videos

Last Updated: May 26, 2026

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

Published on: May 22, 2019

Effect of Yi-Nao-Jie-Yu Prescription on Post-Stroke Depression in Rats using Middle Cerebral Artery Occlusion Combined with Behavioral Restraint

Effect of Yi-Nao-Jie-Yu Prescription on Post-Stroke Depression in Rats using Middle Cerebral Artery Occlusion Combined with Behavioral Restraint

Published on: January 9, 2026

Area of Science:

Neurology
Psychiatry
Public Health

Background:

Post-stroke depression (PSD) affects 20-60% of stroke survivors.
PSD is often linked to stroke severity.
The prevalence of PSD in minor stroke is less understood.

Purpose of the Study:

To investigate the prevalence and predictors of PSD in patients with minor ischemic stroke.
To determine if stroke severity influences PSD rates.

Main Methods:

A cohort of 105 patients with minor ischemic stroke (NIHSS≤5) was followed for 30 months.
Prevalence and predictors of PSD were assessed.
Logistic regression was used to identify significant correlations.

Main Results:

41% of patients developed PSD, with 93% diagnosed with dysthymia.
Depressive symptoms like working inhibition, indecisiveness, and fatigability were common.
Predictors included lower education, diabetes, crying, and guilt; higher education was protective.

Conclusions:

PSD is frequent even in minor stroke cases.
Early identification of specific depressive symptoms can aid in predicting long-term PSD.
Lesion site or side did not correlate with PSD development.