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Micelles

Micelles

Micelle formation is an intricate process that hinges on the properties of amphiphilic or amphipathic molecules and the conditions of the system in which they are found. Amphiphilic molecules, which have both hydrophilic (water-attracting) and hydrophobic (water-repelling) parts, play a critical role in this process.In aqueous environments, these molecules arrange themselves such that their hydrophilic heads are turned towards the water phase, while their hydrophobic tails are oriented away...

Surface Active Agents

Surface Active Agents

Surfactants, named for their behavior at interfaces, positively adsorb at the interfaces of two phases, reducing interfacial tension. Their versatility as emulsifiers, detergents, and foaming agents stems from this ability. Surfactants, often termed amphiphiles, share the property of amphipathy, with molecules having both hydrophilic and hydrophobic portions. The hydrophilic part is called the head, and the hydrophobic part, including an elongated alkyl substituent, forms the tail.Surfactants...

Bioavailability Enhancement: Drug Solubility Enhancement

Bioavailability Enhancement: Drug Solubility Enhancement

Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...

Detergent Purification of Membrane Proteins

Detergent Purification of Membrane Proteins

Detergents are used to purify the integral proteins of the membrane. The hydrophobic portion of the detergent can replace membrane phospholipids while solubilizing the membrane proteins. When detergent monomers reach a specific concentration in a solution called critical micelle concentration (CMC), they form micelles. Above CMC, the concentration of the detergent monomers remains in equilibrium with the micelle. The number of detergent monomers present in the CMC varies for each detergent, and...

Factors Affecting Dissolution: Particle Size and Effective Surface Area

Factors Affecting Dissolution: Particle Size and Effective Surface Area

Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are employed to...

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Related Experiment Video

Updated: May 26, 2026

Microtensiometer for Confocal Microscopy Visualization of Dynamic Interfaces

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Published on: September 9, 2022

Surfactant concentration effects on micellar properties.

Arben Jusufi¹, David N LeBard, Benjamin G Levine

¹Institute for Computational Molecular Science and Department of Chemistry, Temple University, Philadelphia, Pennsylvania 19122, USA. arben.jusufi@csi.cuny.edu

The Journal of Physical Chemistry. B

|December 20, 2011

Summary

This study presents a new theory combining hydrophobic interactions and Debye-Hückel approximation to predict surfactant micellization. The model accurately calculates critical micelle concentration (cmc) and evaluates simulation models.

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Extraction and Characterization of Surfactants from Atmospheric Aerosols

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Studying Surfactant Effects on Hydrate Crystallization at Oil-Water Interfaces Using a Low-Cost Integrated Modular Peltier Device

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Extraction and Characterization of Surfactants from Atmospheric Aerosols

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Published on: April 21, 2017

Area of Science:

Physical Chemistry
Colloid Science

Background:

Surfactant micellization is crucial for various applications.
Predicting critical micelle concentration (cmc) is essential but challenging.
Existing models may not be suitable for all simulation scenarios.

Purpose of the Study:

To develop a predictive theory for surfactant micellization properties.
To validate the theory against experimental data for ionic surfactants.
To extend the theory's applicability to molecular simulation models.

Main Methods:

Combined hydrophobic theory with Debye-Hückel approximation.
Calculated critical micelle concentration (cmc) and concentration effects.
Validated predictions using experimental data of ionic surfactants with salt.

Main Results:

The theory accurately predicts surfactant micellization properties, including cmc.
Experimental data for various ionic surfactants validated the model's predictive power.
The theory successfully describes micellar properties for simulation models.

Conclusions:

The developed theory offers a robust method for predicting surfactant micellization.
This approach enhances the evaluation of surfactant models in molecular simulations.
Provides a valuable tool for understanding and predicting surfactant behavior.