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Optos-guided pattern scan laser (Pascal)-targeted retinal photocoagulation in proliferative diabetic retinopathy
Mahiul M K Muqit1, George R Marcellino, David B Henson
1Manchester Royal Eye Hospital, Manchester, UK.
Acta Ophthalmologica
|December 20, 2011
Summary
Targeted pattern scan laser (Pascal) retinal photocoagulation (TRP) shows promise for treating proliferative diabetic retinopathy (PDR). This pilot study indicates favorable safety and clinical effects, including disease regression and improved visual acuity.
Area of Science:
- Ophthalmology
- Diabetic Retinopathy Research
- Laser Therapy
Background:
- Proliferative diabetic retinopathy (PDR) is a leading cause of vision loss.
- Effective treatment strategies for PDR are crucial for preserving sight.
Purpose of the Study:
- To evaluate the clinical effectiveness and safety of targeted pattern scan laser (Pascal) retinal photocoagulation (TRP) in patients with treatment-naive PDR.
Main Methods:
- A prospective, non-randomized study involving 28 eyes with PDR.
- Single-session 20-ms Pascal TRP with 1500 burns, guided by wide-field fluorescein angiography (Optos).
- Outcomes assessed included PDR grade, central retinal thickness (CRT), visual fields (VF), and visual acuity (VA) at 12 and 24 weeks.
Main Results:
- PDR regression observed in 76% of patients at 12 weeks.
- Significant reductions in CRT and improvements in VF mean deviation (MD) were noted.
- Visual acuity (VA) increased by an average of +3 letters at 24 weeks.
Conclusions:
- Optos-guided Pascal 20-ms TRP with 1500 burns is a promising treatment for treatment-naive PDR.
- The procedure demonstrated a favorable safety profile in this pilot study.
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