Related Experiment Video
Updated: May 26, 2026

A New Method for Inducing a Depression-Like Behavior in Rats
Published on: February 22, 2018
Variables modulating depression in dementia caregivers: a longitudinal study
R Romero-Moreno1, M Márquez-González, B T Mausbach
1Psychology Department, Universidad Rey Juan Carlos de Madrid, Alcorcón, Madrid, Spain. rosa.romero@urjc.es
Background:
Dementia caregiving has been linked to negative consequences for mental health in caregivers. Although depression seems to be an enduring psychological consequence associated with caregiving, little is known about the longitudinal effects that modulating variables related to coping strategies have on caregiver's changes in depression over time. This study is aimed at investigating whether, in a one-year longitudinal study with 130 dementia caregivers, caregivers' depression scores co-vary with modulating variables such as self-efficacy for controlling upsetting thoughts, frequency of leisure activities, and cognitive reappraisal, after controlling for gender and caregivers' stressors (frequency of disruptive behaviors).
Methods:
Linear mixed models analysis was used to analyze the associations between time-varying values for caregivers' stressors and modulating variables in predicting caregivers' depression.
Results:
It was found that increases in caregivers' self-efficacy, frequency of leisure activities, and cognitive reappraisal significantly predicted decreases in caregivers' depression over time, even after controlling for gender and frequency of disruptive behaviors. In addition, increases in stressors were significantly related to increases in depression over time.
Conclusions:
The inclusion of modulating variables significantly contributed to the explanation of the variance in caregivers' depression, adding explanatory power to the variables usually included in the stress and coping model (gender and stressors).
Related Concept Videos
Long-term Depression
Long-term Depression
Calcium Ion Concentration Mechanism
If over time, all...
Depressive Disorders: MDD and Dysthymia
Depressive Disorders: Etiology
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Depression: Overview
Alzheimer's Disease: Treatment