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Published on: August 13, 2019
EMAS clinical guide: selective estrogen receptor modulators for postmenopausal osteoporosis
Santiago Palacios1, Mark Brincat, C Tamer Erel
1Palacios Institute of Woman's Health Antonio Acuna, Madrid, Spain. ipalacios@institutopalacios.com
Maturitas
|December 20, 2011
Summary
Selective estrogen receptor modulators (SERMs) offer a viable treatment option for postmenopausal osteoporosis management. This guide reviews the clinical evidence for SERM use in preventing fractures and improving bone health in aging women.
Area of Science:
- Gerontology
- Endocrinology
- Public Health
Background:
- Osteoporosis and associated fractures represent a significant global health challenge, exacerbated by an aging population.
- Current therapeutic options include bisphosphonates, strontium ranelate, and denosumab.
- Effective management strategies are crucial for maintaining bone health and reducing fracture risk in vulnerable populations.
Purpose of the Study:
- To provide a clinical guide on the evidence supporting the use of selective estrogen receptor modulators (SERMs) in managing osteoporosis.
- To evaluate the efficacy and safety of SERMs for postmenopausal women with osteoporosis.
- To inform clinical decision-making regarding SERM therapy in osteoporosis treatment.
Main Methods:
- Systematic review of clinical trials and observational studies on SERMs for osteoporosis.
- Analysis of data on bone mineral density, fracture incidence, and adverse events associated with SERM use.
- Evidence-based assessment of SERMs in the context of existing osteoporosis therapies.
Main Results:
- SERMs have demonstrated efficacy in increasing bone mineral density and reducing vertebral fracture risk in postmenopausal women.
- Comparative data suggests SERMs offer a distinct therapeutic profile compared to other osteoporosis treatments.
- Safety profiles and specific indications for SERM use are detailed.
Conclusions:
- Selective estrogen receptor modulators (SERMs) are a valuable therapeutic class for managing postmenopausal osteoporosis.
- Evidence supports the use of SERMs for fracture prevention and bone health improvement.
- SERMs provide an important treatment option for postmenopausal women, complementing other available therapies.
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