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Updated: May 26, 2026
06:13
Endoscopic Septoplasty with Limited Two-line Resection: Minimally Invasive Surgery for Septal Deviation
Published on: June 20, 2018
[Macrolide therapy on nasal mucosal persistent refractory inflammation after endoscopic sinus surgery]
1Othrhinolaryngology Hospital, First Affiliated Hospital, SUN Yat-san University, Otorhinolaryngology Institute of SUN Yat-san University, Guangzhou 510080, China.
Summary
Low-dose, long-term use of Klacid (clarithromycin) effectively treats persistent inflammation after endoscopic sinus surgery (ESS) for chronic rhinosinusitis (CRS). This treatment is safe and well-tolerated, improving both symptoms and endoscopic outcomes.
Area of Science:
- Otolaryngology
- Pharmacology
- Inflammation Research
Background:
- Chronic rhinosinusitis (CRS) often involves persistent, refractory inflammation of the paranasal sinus mucosa.
- Endoscopic sinus surgery (ESS) is a common treatment for CRS, but some patients experience persistent inflammation postoperatively.
- Macrolide antibiotics, such as Klacid (clarithromycin), have demonstrated anti-inflammatory properties.
Purpose of the Study:
- To evaluate the clinical efficacy of low-dose, long-term Klacid in managing persistent refractory inflammation following ESS.
- To assess the safety and tolerability of this treatment regimen in CRS patients.
Main Methods:
- A study involving 13 patients with persistent refractory inflammation post-ESS for CRS.
- Patients received low-dose Klacid (250 mg/d) for 12-28 weeks, alongside standard treatments.
- Outcomes were assessed using visual analogue scale for symptoms and Lund-Kennedy scoring for nasal endoscopy.
Main Results:
- Twelve of 13 patients completed the treatment, showing remarkable improvement in both subjective symptoms and objective endoscopic findings.
- Overall outcomes were rated as very good in 6 patients and good in 6 patients.
- No recurrent sinusitis or adverse side effects were reported during the 6-month follow-up period.
Conclusions:
- Low-dose, long-term Klacid is an effective treatment for persistent refractory inflammation of the nasal mucosa after ESS in CRS patients.
- Klacid demonstrates a favorable safety profile and good tolerability for this patient group.
- This therapeutic approach offers significant clinical benefits for managing challenging post-ESS inflammation.
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