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Updated: May 26, 2026
08:32
Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production
Published on: March 2, 2014
Viperin: a multifunctional, interferon-inducible protein that regulates virus replication
Jun-Young Seo1, Rakina Yaneva, Peter Cresswell
1Department of Immunobiology, Yale University School of Medicine New Haven, CT 06520-8011, USA.
Cell Host & Microbe
|December 20, 2011
Summary
Viperin, an interferon-inducible protein, inhibits viral replication through various mechanisms and influences intracellular signaling and cellular metabolism, particularly when expressed in mitochondria. This review explores the multifaceted roles of this unique molecule.
Area of Science:
- Immunology
- Virology
- Molecular Biology
- Cellular Metabolism
Background:
- Viperin is an interferon-inducible protein with known antiviral functions.
- Its diverse mechanisms of action and roles in cellular processes are not fully understood.
- Expression in mitochondria impacts cellular metabolism.
Purpose of the Study:
- To review the current understanding of viperin's multifaceted roles.
- To consolidate knowledge on viperin's antiviral, signaling, and metabolic functions.
- To highlight viperin's significance in cellular responses to viral infections.
Main Methods:
- Literature review of existing studies on viperin.
- Analysis of research on viperin's interactions with viruses.
- Examination of studies investigating viperin's role in signaling and metabolism.
Main Results:
- Viperin inhibits replication of diverse viruses via multiple mechanisms.
- Viperin participates in intracellular signaling pathways.
- Mitochondrial viperin expression affects cellular metabolic pathways.
Conclusions:
- Viperin is a versatile protein with significant roles in antiviral defense, intracellular signaling, and metabolism.
- Further research is needed to fully elucidate viperin's complex functions.
- Viperin represents a key molecule in the host's response to viral infections.
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