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Updated: May 26, 2026
08:46
Studying Age-dependent Genomic Instability using the S. cerevisiae Chronological Lifespan Model
Published on: September 29, 2011
[Chronodisruption and ageing]
Elisabet Ortiz-Tudela1, María de los Ángeles Bonmatí-Carrión, Mónica De la Fuente
1Departamento de Fisiología, Facultad de Biología, Universidad de Murcia, Murcia, España.
Revista Espanola De Geriatria Y Gerontologia
|December 20, 2011
Summary
Modern lifestyles disrupt our internal body clocks, causing chronodisruption (CD) and premature aging. Regular exposure to light, meals, and activities can prevent age-related CD.
Area of Science:
- Chronobiology
- Physiology
- Epidemiology
Context:
- Modern lifestyles promote nocturnal activity, reduce sleep, and cause time zone shifts (jet lag, shift work).
- This leads to chronodisruption (CD), a disturbance of circadian rhythms.
- CD is linked to metabolic syndrome, cardiovascular disease, cognitive impairment, cancer, and premature aging.
Purpose:
- To define chronodisruption (CD) and its health consequences.
- To explore the mechanisms of CD within the circadian system.
- To highlight the role of synchronizers in preventing age-related CD.
Summary:
- Chronodisruption (CD) is a significant disturbance of biochemical, physiological, and behavioral circadian rhythms.
- Epidemiological studies link CD from shift work, jet lag, and light exposure to various diseases and premature aging.
- Disturbances in the central pacemaker, peripheral oscillators, or their inputs/outputs can cause CD.
Impact:
- Understanding CD is crucial for public health, given its association with numerous chronic diseases.
- Identifying factors contributing to CD can inform interventions to mitigate health risks.
- Regularly timed environmental cues (synchronizers) can promote "chronoenhancement" and counteract age-related circadian disruption.
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