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The effects of ApoE gene polymorphisms on lumbar spine bone mineral density and carotid atherosclerosis

Jianming Hou1, Huinan Wu

  • 1Department of Endocrinology, Provincial Clinic College of Fujian Medical University, Provincial Hospital of Fujian, Fuzhou 350001, China. hjm996@yahoo.com.cn

Clinical Biochemistry
|December 20, 2011
PubMed

Insights

The ApoE4 genotype is linked to carotid atherosclerosis in elderly men, but not to reduced bone mineral density in the lumbar spine. This suggests ApoE4 influences vascular health independently of bone density.

Area of Science:

  • Genetics
  • Cardiovascular Medicine
  • Osteoporosis Research

Background:

  • Carotid atherosclerosis (CA) and osteoporosis are common in elderly populations.
  • The role of ApoE gene polymorphisms in these conditions requires further investigation.

Purpose of the Study:

  • To investigate the correlation between osteoporosis and carotid atherosclerosis (CA).
  • To explore the effects of ApoE gene polymorphisms on lumbar spine bone mineral density (BMD) and CA in elderly Han males.

Main Methods:

  • A study involving 221 elderly Han males.
  • Participants were categorized into control, CA, low BMD, and combined CA/low BMD groups.
  • ApoE gene polymorphisms were analyzed in all groups.

Main Results:

  • The incidence of ApoE4 isoforms was significantly higher in the CA group compared to controls (P<0.05).
  • No significant differences in ApoE4 isoform or genotype incidence were observed between the low BMD groups (BMD↓ and CA+BMD↓) and the control group.
  • ApoE4 genotype incidence did not differ significantly across the CA, BMD↓, and CA/BMD↓ groups.

Conclusions:

  • The ApoE4 genotype may serve as a risk factor for developing carotid atherosclerosis.
  • The ApoE4 genotype does not appear to be correlated with bone mineral density in the lumbar spine of elderly Han males.
Abstract

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