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The iron transporter ferroportin can also function as a manganese exporter

Michael S Madejczyk1, Nazzareno Ballatori

  • 1Department of Environmental Medicine, University of Rochester School of Medicine, Rochester, NY, USA. Mike_Madejczyk@urmc.rochester.edu

Biochimica Et Biophysica Acta
|December 20, 2011
PubMed
Summary

Ferroportin (FPN1/SLC40A1), known for iron export, also facilitates manganese export. This study shows FPN1 transports manganese, influenced by pH and ion gradients, impacting cellular metal homeostasis.

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