Related Experiment Video
Updated: May 26, 2026
Measurement of Tissue Oxygenation Using Near-Infrared Spectroscopy in Patients Undergoing Hemodialysis
Published on: October 2, 2020
[Cross-sectional study of relation between blood pressure and heart rate variability in patients with peritoneal
Li-xian Li1, Wen Tang, Bo-jun Chen
1Department of Nephrology, Peking University Third Hospital, Beijing 100191, China.
Insights
Heart rate variability (HRV) analysis reveals distinct autonomic nerve function (ANF) patterns in peritoneal dialysis (PD) patients. Sympathetic overactivity is linked to hypertension, while parasympathetic activity dominates in hypotension, highlighting HRV as a key blood pressure indicator in PD.
Area of Science:
- Cardiology
- Nephrology
- Physiology
Context:
- Peritoneal dialysis (PD) is a vital renal replacement therapy.
- Autonomic nerve function (ANF) plays a crucial role in cardiovascular regulation.
- Understanding the interplay between ANF and blood pressure (BP) in PD patients is essential for managing complications.
Purpose:
- To investigate the relationship between heart rate variability (HRV) and blood pressure (BP) in patients undergoing continuous ambulatory peritoneal dialysis (CAPD).
- To assess autonomic nerve function (ANF) through HRV parameters in different BP categories within the PD population.
Summary:
- This cross-sectional study analyzed 93 CAPD patients, categorizing them by BP. Heart rate variability (HRV) indices, reflecting ANF, were measured using time-domain and frequency-domain analyses.
- Results indicated significantly lower HRV indices and a higher LF/HF ratio in the hypertensive group compared to the normal BP group.
- Correlation analyses revealed negative associations between BP and most HRV indices, and a positive correlation with the LF/HF ratio. Multivariable analysis confirmed HRV indicators as independent factors influencing BP in PD patients.
Impact:
- The findings demonstrate that ANF, as assessed by HRV, differs significantly across various blood pressure statuses in PD patients.
- Parasympathetic nerve activation is observed in hypotension, whereas sympathetic nerve activation is prominent in hypertension.
- HRV serves as an independent factor associated with blood pressure regulation in PD patients, suggesting its potential as a monitoring tool.
Objective:
To analyze the possible relationship between heart rate variability (HRV) and blood pressure in peritoneal dialysis patients.
Methods:
In this cross-sectional study, 93 continuous ambulatory peritoneal dialysis patients (CAPD) patients were enrolled. Patients were divided into three groups according blood pressure. HRV which reflects autonomic nerve function (ANF) were measured by using 5-minutes recordings of a stationary system by a standardized method. Both time-domain and frequency domain parameters were analyzed.
Results:
HRV time domain indices [the standard deviation of all normal RR intervals (SDNN), the square root of the mean of the squared differences between adjacent normal RR intervals (rMSSD), the standard deviation of differences between adjacent NN intervals (SDSD), the percentage of differences between adjacent normal RR intervals that were >50 ms computed (PNN50)] and frequency domain indices [the low-frequency energy in the power spectrum 0.04-0.15 Hz (LF), the high-frequency energy in the power spectrum 0.15-0.4 Hz (HF)] were significantly lowest in hypertensive group (P<0.05) whereas LF/HF was highest as compared to normal BP group (P<0.05). Univariable correlation analysis showed that both systolic and diastolic blood pressure were negatively correlated with SDNN (r=-0.386, P<0.001; r=-0.399, P<0.001), rMSSD (r=-0.373, P<0.001; r=-0.426, P<0.001), SDSD (r=-0.375, P<0.001; r=-0.425, P<0.001), PNN50 (r=-0.223, P=0.032; r=-0.245, P=0.018), TP (r=-0.328, P=0.001; r=- 0.312, P=0.002), LF (r=-0.260, P= 0.012; r=-0.194, P=0.063), HF (r=-0.394, P<0.001; r=-0.365, P<0.001), and positively correlated with LF/HF (r=0.275, P=0.008; r=0.171, P=0.1). Multivariable regression analysis showed that HRV indicators were independently factor affecting both systolic and diastolic blood pressure in PD patients.
Conclusion:
ANF assessed by HRV were significantly different in PD patients with blood status, parasympathetic nerve were activated in hypotension group whereas sympathetic nerve were activated in hypertension group. ANF was independently factors associated with blood pressure.
Related Concept Videos
01:25Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications
01:25Hemodialysis III: Nursing Management
01:28Special considerations while measuring blood pressure
Monitoring Both Arms:
Monitoring BP in both arms during the initial assessment is advisable, as the systolic value may differ by five to ten mm Hg between arms. For subsequent BP assessments, use the arm with the higher reading.
01:25Peritoneal Dialysis III: Nursing Management
01:19Assessing Blood pressure using a doppler ultrasound
Pre-Procedural Guidelines for Doppler Ultrasound Blood Pressure Assessment:
Preparation of Equipment:
01:23Assessment of blood pressure in brachial artery(two-step method)