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A sensing array of radically coupled genetic 'biopixels'.

Arthur Prindle1, Phillip Samayoa, Ivan Razinkov

  • 1Department of Bioengineering, University of California, San Diego, La Jolla, California 92093, USA.

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|December 20, 2011
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Summary
This summary is machine-generated.

Researchers engineered synchronized bacterial colonies to create a macroscopic clock. This synthetic biology advance enables large-scale genetic biosensors for detecting environmental toxins like arsenic.

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Area of Science:

  • Synthetic Biology
  • Microbial Engineering
  • Systems Biology

Background:

  • Cellular environments present challenges for synthetic biology circuits due to noise and intercellular variability.
  • Variability hinders the functionality of engineered biological circuits at the colony level.

Purpose of the Study:

  • To engineer synchronized oscillations in thousands of bacterial colonies over centimeter-length scales.
  • To develop a platform for large-scale coordination of engineered cellular behavior.
  • To construct a macroscopic clock for sensing environmental contaminants.

Main Methods:

  • Utilized synergistic intercellular coupling mechanisms, including quorum sensing within colonies and gas-phase redox signaling between colonies.
  • Engineered bacterial 'biopixels' to oscillate and synchronize their behavior.
  • Integrated synchronized biopixels into a liquid crystal display (LCD)-like macroscopic clock structure.

Main Results:

  • Achieved synchronization of thousands of oscillating bacterial colonies over centimeter-length scales.
  • Successfully constructed a macroscopic clock capable of sensing arsenic by modulating its oscillatory period.
  • Demonstrated the potential for coordinating bacterial behavior at a large scale.

Conclusions:

  • The engineered synchronization platform overcomes cellular noise and variability challenges in synthetic biology.
  • This work enables the development of low-cost, field-deployable genetic biosensors for detecting heavy metals and pathogens.
  • Coordinated bacterial behavior at large scales opens new avenues for microbial engineering and environmental monitoring.